During the preparation of solutions, the following approach can be used to improve the aqueous solubility of a particular drug:
A. Increasing the particle size of a
poorly soluble drug
B. Decressing the pH of the solution
when the drug is a weak base
C. Addition of a water miscible
solvent in which the non-polar
compound is soluble
D. Reaction of an insoluble drug and
soluble material to form a soluble
intermolecular non-reversible
complex​