Although lee opposed the idea of secession, he could not take up arms against his home state of

General Lee would not take up arms against his own state of Virginia. He was the commander of the Confederate states of America. He commanded the army of Northern Virginia from 1862 until 1865 when he surrendered. He was one of the great generals of the Civil War.

The answer is Virginia. Lee's home state was Virginia. "Although, Lee countered the idea of secession, he was cannot take up arms, which is opposing his home state, which is known to be the state of Virginia. Virginia is surrounded between Maryland and Washington D.C.