Suppose you are a settler in the brittish colonies. you want to settle on land where the ohio river meets the mississippi river. traveling over land, what might be a good route?

The major physical feature that you would have to cross in order to reach this destination would be the Appalachian Mountains, since these were so large that they discouraged travel to this region for quite some time. 

they made rome the dominant power in the mediterranean.

"germany's geographic location was an advantage when it was on the offensive in the war because it was situated next to an extremely wide river, the rhine, which was difficult for the allies to cross."