Alimitation of retrovirus-mediated gene transfer is that

The answer is Retroviruses integrate DNA randomly in the genome. While retroviruses integrate their DNA permanently in their host genome, hence a good tool for gene therapy, its risk of inserting DNA at an unintended location on target genome can cause insertional mutagenesis. This mutation can cause activation of oncogenes hence lead to tumor growth.

answer; the above statement is (true);

"1. it should be, it has been for about 20 years, and it's really not much different in the end than breeding animals to have particular traits. there are always concerns about genetically engineered animals/plants affecting the environment in unexpected negative ways, but i can't think of an example where the fears didn't turn out to be baseless.  

first, as you point out, it would be a great advance in pharmacology, to be able to tailor drugs and their doses to me. the pros involve better medical treatment. the cons involve privacy issues like insurance companies denying coverage to people with genetic risk factors. looking at dna markers wouldn't affect the frequency of genetic diseases, but it would allow detection of them earlier. and ok, actually i suppose that if people used this information to avoid having children with genetic diseases, some might decrease in frequency."