A group of mutations, known as MT-ND1 , have been identified in mitochondrial DNA . These mutations are associated with a number of debilitating diseases stemming from the production of nonfunctional proteins in the mitochondria. Which of the following cellular deficiencies would most likely be related to these MT-ND1 mutations?

A. The cell is unable to synthesize most proteins required for normal cell functions.
B. The cell is unable to break down toxic materials and would accumulate large volumes of these materials.
C. The cell is able to synthesize proteins, but the proteins would not fold properly and would not contain the correct molecular tags for export from the cell
D. The cell is unable to complete reactions related to electron transport and ATP production

The kidney filters potentially toxic substances in the blood, and thus “clears” the blood of those substances. this clearance function is dependent upon and proportional to the diffusion gradient of the substance across filtering capillaries, i.e. if the concentration of the substance is doubled, twice as much will be cleared from each ml of blood that is filtered. suppose that the body produces a constant amount of a substance x per unit of time. the kidneys eliminate substance x at a rate directly proportional to the concentration of the substance and the volume of blood cleared each minute (c): elimination = c × [x], where [x] is the steady-state concentration of substance x. imagine an individual with an initial concentration of x equal to [x]0 who develops kidney disease. her baseline clearance c0 drops to one half of the original (½c0). what is the new steady state concentration of x? (for simplicity, assume that substance x is 100% filtered by the kidney).