10. What is the structure of chromatin and how does it affect gene regulation?

Chromatin accessibility is regulated by nucleosome remodeling, utilization of histone variants, DNA methylation, and posttranslational modifications (PT.Ms). Chromatin remodeling complexes can slide nucleosomes, rotate the DNA helix relative to the nucleosome to expose T.F binding sites, or evict nucleosomes. imma say Chromatin structure plays a key role in regulating gene expression by allowing DNA accessibility to transcriptional machinery and transcription factors 12.

Explanation:

the sugar-phosphate backbone forms the structural framework of nucleic acids, including dna and rna. this backbone is composed of alternating sugar and phosphate groups, and defines directionality of the molecule.