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Biology, 07.04.2020 23:01 dashavasilisk
When the acetyl-CoA produced during -oxidation in the liver exceeds the capacity of the citric acid cycle, the excess acetyl-CoA is used to synthesize ketone bodies – acetone, acetoacetate, and -hydroxybutyrate. This occurs in severe, uncontrolled diabetes: because the tissues cannot use glucose, they instead oxidize large amounts of fatty acids. Although acetyl-CoA is not intrinsically toxic, the mitochondrion must divert the acetyl-CoA to ketone bodies. What problem would arise if acetyl-CoA were not converted to ketone bodies? How does the diversion to ketone bodies solve the problem?
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When the acetyl-CoA produced during -oxidation in the liver exceeds the capacity of the citric acid...
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