extreme pressure and temperatures can change sedimentary rock into _

It transforms to metamorphic rock

Explanation:

When sedimentary rock is exposed to higher temperatures and bigger pressures, usually deep into the ground, it slowly transforms overtime into a certain type of metamorphic rock.

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme

true, i don't really know what you're asking but from the info you provided im guessing the answer is true.