A map titled The Extent of Christianity. A key shows Christianity, circa 300 C E in purple, Christianity, circa 600 C E in orange, and Modern borders with a gray line. Purple shaded areas include Jerusalem, Palestine, and areas in the Mediterranean including regions of Greece, Rome, and Carthage, in North Africa. Orange shaded areas include Spain, Portugal, England, France, Italy, countries in Central Europe, Greece, Turkey, and North Africa. How did the Edict of Milan, which was issued in 313 CE, affect the spread of Christianity? It allowed Christianity to spread to Carthage and Jerusalem. It allowed Christianity to spread outside of Europe by 600 CE. It allowed Christianity to spread around the entire world by 600 CE. It allowed Christianity to spread throughout the entire Roman Empire.