Who would be most likely to agree with German's Rubicon reference (A) John Calhoun and other politicians from the South
(B) Henry Clay and other politicians from the West
(C) Officials from the executive branch
(D) Merchants from New England

The answer is "Option B".

Explanation:

When trying to cross the rubicon is a term, which includes getting an irreversible move in the wrong direction. While in 49 B.C.E. Julius Caesar would have to cross the small Rubicon, he referenced a play from Menander called "anerriphtho kybos!", in which Henry Clay and other Western politicians would most probably accept the German connection to Rubicon.

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