How did European settlement and exploration of the early 15th century result in the death of many American Indians? 1.)American Indians were relocated to areas that lacked the proper resources for health and survival.

2.)American Indians were forced to take sides in battles over land between competing Europeans.

3.)American Indians suffered from starvation and exposure while serving as guides to explorers.

4.)American Indians lacked immunities to the many European diseases they came into contact with.