Historians believe that the people who accused their neighbors of witchcraft in Salem, Massachusetts in the 1600's may have been suffering from poisoning.

Ergot  

Explanation:

Historians believe that the people who accused their neighbors of witchcraft in Salem, Massachusetts in the 1600's may have been suffering from ergot poisoning.  Ergot is a fungus that grow on rye and its ingestion can lead to illness and fatality. Early symptoms of ergot poisoning includes muscle pain and weakness, numbness, itching, and rapid or slow heartbeat, and vomiting.

Interestingly, historians believe ergot played a role in the Salem witch hunt of 1692, they believe that some women suffering from symptoms of ergotism accused their neighbors of being witches.

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