With insufficient folate intake, immature cannot divide because they cannot form enough new for two new nuclei, and so the cells grow progressively larger.

i. red blood cells

ii. DNA

Explanation: The reduction of mature red blood cells which results from this decreases the capacity of the blood to carry oxygen; the cells therefore remain in a large immature form known as a megaloblast. As this occurs over time, it causes the folate deficiency condition called macrocytic anemia, or megaloblastic anemia.

There's another type of anemia that clinically looks like folate-related anemia due to the enlargement of red blood cells and this is called pernicious anemia. It occurs as a result of insufficient vitamin B-12 intake.

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