The combined effect of many weak interactions can be very significant in determining factors such as three-dimensional structure for large biological molecules.

the answer is non covalent interaction

Explanation:

The combined effect of many weak non covalent interactions can be very significant in determining factors such as three-dimensional structure for large biological molecules.

The weak non covalent interactions such as ionic bond, hydrophobic interactions, hydrogen bonds, Van der Waals forces and dipole–dipole bonds plays an important role in bonding large biological molecules such as protein and nucleic acid.

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