What should you do in the intermediate steps of a numerical calculation? Include an error estimate at each step.

Round the result of every arithmetic operation to the number of significant figures in the input numbers.

Express each number in scientific notation.

Keep at least a couple of extra digits beyond those needed for determining significant figures.

Asubject in a clinical research trial experiences a serious, unanticipated adverse drug experience. how should the investigator proceed, with respect to the irb, after the discovery of the adverse event occurrence? a. do not report the adverse drug experience to the irb since it is a common adverse experience.b. report the adverse drug experience to the irb only if there are several other occurrences.c. report the adverse drug experience as part of the continuing review report.d. report the adverse drug experience in a timely manner, in keeping with the irb's policies and procedures, using the forms or the mechanism provided by the irb.