I need help with 1-3 and 6-9

its do today need help with all of the questions plz

Asubject in a clinical research trial experiences a serious, unanticipated adverse drug experience. how should the investigator proceed, with respect to the irb, after the discovery of the adverse event occurrence? a. do not report the adverse drug experience to the irb since it is a common adverse experience.b. report the adverse drug experience to the irb only if there are several other occurrences.c. report the adverse drug experience as part of the continuing review report.d. report the adverse drug experience in a timely manner, in keeping with the irb's policies and procedures, using the forms or the mechanism provided by the irb.

A5 foot by 5 foot box culvert is buried 6 feet beneath the surface of the ground. a crosssection of this very long culvert (into and out of the page) is illustrated below. assume that the soil in which the culvert is buried has the following properties: jt = 120 pcf, w = 12%, ko = 0.50, ka = 0.33, and kp = 3.00. calculate the total horizontal force per unit length of culvert (fh) felt on one of the vertical faces of the culvert.

An alpha particle with kinetic energy 12.5 mev makes a collision with lead nucleus, but it is not "aimed" at the center of the lead nucleus, and has an initial nonzero angular momentum (with respect to the stationary lead nucleus) of magnitude l = p0 b, where p0 is the magnitude of the initial momentum of the alpha particle and b=1.40×10−12 m. (assume that the lead nucleus remains stationary and that it may be treated as a point charge. the atomic number of lead is 82. the alpha particle is a helium nucleus, with atomic number 2.) what is the distance of closest approach?