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Explain the pathophysiologic changes that can cause the signs and symptoms associated with common bile duct obstruction.

Anurse is caring for a client who has nicotine use disorder and asks about taking varenicline. the nurse should identify that which of the following conditions is a contraindication for this medication? a. rheumatoid arthritis b. copd c. anorexia nervosa d. major depressive disorder

One possible issue in adherence to medication regimen. explain how this can be overcome.