You have discovered a novel steroid hormone. you'd like to isolate its receptor as part of question: you have discovered a novel steroid hormone. you'd like to isolate its receptor as part of your you have discovered a novel steroid hormone. you'd like to isolate its receptor as part of your next project. where should you look first? a) on the cell surface b) in the blood stream c) in the cytoplasm d) any of these might be places where the receptor could be found

Hormones are molecules secreted by different cells whose job is to stimulate other cells and produce an action in them. There are many types of hormones, and depending on their chemical configuration, they will be able to access a cell and activate its working mechanisms through contact with receptors present on the cell´s plasma membrane, or through intracellular receptors found in both the cytoplasm, and on the cell´s nucleus.

In the case of steroid hormones, given that their molecular structure is built from lipids, they are actually able to cross the plasma membranes of target cells through diffusion, and in the bloodstream they need to be carried by transport proteins, given that in essence, being lipidic, they tend to be hydrophobic. These steroid hormones do not bind to receptors of cells on their plasma membrane; rather, they have direct contact with the intracellular cytoplasm, its organelles and the nucleus, where they will carry out their message.

So, the best answer to your question, given what was explained above, would be: D: In the cytoplasm, because the target cells will have the necessary receptor types for the specific steroid hormone that has crossed the plasma membrane in their cytoplasm and nucleus.