At rest in muscle cells, the em is not constant but shows seemingly random fluctuations that appear to be in units of about 0.5 mv. these are called miniature endplate potentials (mepp) and are due to the fusion of a single vesicle containing acetylcholine with the presynaptic nerve terminal membrane.
(a) if the muscle cell is 50 μm in diameter and 10cm long, and its specific capacitance is 1 μf/cm2, how much charge must flow for this 0.5mv change due to a single vesicle fusion event?
(b) if ena = +66mv and em = -85mv, and the mepp rises in 0.5 ms, what is the average conductance increase in the membrane due to the single fusion event? assume the current is all carried by na+.
(c) how many channels do you think open during the mepp? use 40 ps for the unitary conductance of the acetylcholine receptor.

Sam and joan have been married for 25 years and have three children: max, who is 23; janet, who is 19; and sarah, who is 15. janet has just been diagnosed with a mental illness. describe the objective and subjective burdens each family member may experience. describe the meaning this diagnosis may have to janet’s parents, younger sibling, and older sibling.

Anurse is caring for a client who has nicotine use disorder and asks about taking varenicline. the nurse should identify that which of the following conditions is a contraindication for this medication? a. rheumatoid arthritis b. copd c. anorexia nervosa d. major depressive disorder

Name the bone/structure/process that fits the following description: a) a bone with a complex shape. b) found in the medullary cavity. c) a large, rough process. d) it is thin, like a plate. e) shaft of a long bone. f) a mature bone cell. g) a large, round, smooth process. h) it covers outer surface of bone. i) a shallow depression on surface of bone. j) a roughly cube-shaped bone. k) the covering of epiphysis. l) a very narrow ridge of bone. m) space between lamellae for an osteocyte. n) chamber within diaphysis o) also called wormian bone. p) it secretes new matrix. q) end of a long bone. r) a small, round hole. s) a matrix, arrangement in spongy bone. t) it is a chamber within a bone. u) a network allowing osteocytes to receive nutrients. v) one example is the patella. w) it houses artery, vein and nerve. x) almost flat, smooth surface of a bone. y) a narrow, pointed process.