What is the likely pathogenesis of cyclic neutropenia and what would a bone marrow biopsy show?

It is stated that a mutation of the neutrophil elastase protein gene ELA 2 produces a granulopoiesis defect.

Bone marrow aspiration will show a mature metamyelocyte arrest.

Explanation:

Cyclic neutropenia is a rare hereditary congenital disease. Until 2002, there were only 194 registered cases. A mutation of the neutrophil elastase protein gene (ELA2) located on chromosome 19 produces a granulopoiesis defect. This causes neutropenia in peripheral blood every 3 to 4 weeks. These episodes are accompanied by fever, aphthous stomatitis, gingivitis, pharyngitis or cervical adenopathies. Severe infections such as pneumonia, sepsis or peritonitis occur in 10% of cases. Cyclic neutropenia usually progresses to chronic neutropenia.

source: https://www.analesdepediatria.org/es-neutropenia-ciclica-tratamiento-con-factor-articulo-S1695403308001100

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explanation:

you did not provide anything to go off of.

answer:

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