Lisa needs to score at least 12 points on her next turn to win the game. write an inequality to represent the number of points lisa needs to win the game

L will be the number of points Lisa needs to win the game. She needs at least, so you know the sign will include "or equal to". Now, she can score over 12 points to win on her next turn, so we'll be using ≥.
L ≥ 12  will be the inequality for this situation.

Difference means subtraction