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Mathematics, 06.09.2021 22:50 kidyugey

Multinomial Base Pair Sampling: The reference human genome has 23 chromosomes. These 23 chromosomes have an average of 2,973,516,044 base pairs in men. However, human cells are diploid, so there is a copy of chromosomes 1-22 in each cell (44 of 46 chromosomes). The remaining chromosomes in women are an XX pair, while men have an XY pair. Thus, in actual cells, you would have double the number of base pairs of the reference genome (so more than 5.9 million base pairs for men). Considering the following: Chromosome # of base pairs
1 247,199,719
9 140,442,298
Y 57,741,652

Required:
When analyzing a set of 9 base pairs from DNA extracted from one of your father's cells, what is the probability that 4,3, and 2 base pairs come from chromosomes 1, 9, and y, respectively?

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