What caused thousands of deaths among native americans when the europeans came? the started the first colony in today’s louisiana what was the natchez uprising? la salle discovered the mouth of the mississippi river question 4 options: true false the french cooperated with the indians to profit from the fur trade question 5 options: true false when spain owned louisiana, it was a buffer zone between the british colonies and which country ? who established spain’s authority in louisiana? why did the american colonies rebel against the british? which of the following made up the largest group of immigrants to louisiana during the spanish period? directly after the french and indian war, new orleans belonged to france question 10 options: true false