What are settler-colonies? What impact did disease have on these areas?

Settler colonies were areas outside Europe in which so many European immigrants voluntarily settled that their numbers were large enough to secure their political dominance, even if they were in a minority among the indigenous population. Perhaps the single greatest impact of European colonization on the North American environment was the introduction of disease. Microbes to which native inhabitants had no immunity caused sickness and death everywhere Europeans settled.

Explanation:

i'd assume india mainly because of how isolated japan was.   plus it is a whole china away.