Was interaction with Europeans more helpful OR harmful for the Native peoples of the Americas?

Perhaps European colonization's single greatest impact on the North American environment was the introduction of disease. Microbes to which native inhabitants had no immunity led to death everywhere Europeans settled.

there are no answer given

explanation:

"globalization has greatly impacted the united states and american citizens. first and foremost, globalization has spread american influence throughout the world. globalization has opened up more markets for the united states, which in effect american companies sell their products worldwide. there has been a rise of multinational corporations and their influence has greatly increased."