Is living in close quarters was the only reason disease spread in Europe.​

No, the sanitation was quite bad, and the streets were covered in feces. The water supply was usually infected with disease, and people believed that the water helped them, so it got even worse.

Explanation:

the answer to your question is:

strong-mayor system

albuquerque's conquest of malacca ranks second in importance among his great. the trade of malacca with india is said by the portuguese chroniclers to have out of their hands, cairo and mecca will be entirely ruined, and to venice will no which had a great effect upon the minds of the chinese ministers