How did american indians react to white settlers in northwest territory

They, attacked the settlers which lead to the Northwest Indian War that lasted from 1785 to 1795 this was also  known as the Ohio War, Little Turtle's War, and by other names,  it was a war between the United States and a confederation of numerous Native American tribes, with support from the British, for control of the Northwest Territory. It followed centuries of conflict over this territory, first among Native American tribes, and then with the added shifting alliances among the tribes and the European powers of France and Great Britain and their colonials. 

The answer is challenging and taxing because arduous means when something is hard and tiring and the excerpt provides clear detail why that's the answer