During the 1925 scopes trial, the defense’s main argument was that

The best and most correct answer among the choices provided by your question is the first choice.

During the 1925 Scopes trial, the defense’s main argument was that
Scopes was being discriminated against.

I hope my answer has come to your help. Thank you for posting your question here in . We hope to answer more of your questions and inquiries soon. Have a nice day ahead!