How did american indians react to white settlers in the northwest territory

They attack the settlers. which lead to  The Northwest Indian War (1785–1795) also, known as the Ohio War, Little Turtle's War, and by other names, was a war between the United States and a confederation of numerous Native American tribes, with support from the British, for control of the Northwest Territory. It followed centuries of conflict over this territory, first among Native American tribes, and then with the added shifting alliances among the tribes and the European powers of France and Great Britain, and their colonials. 

The second option is correct according to edgenuity

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