During the 1600s and 1700s, the economies of the middle colonies
grew as they became centers of trade because of their location.
grew as sugar and cotton plantations flourished in virginia and maryland.
stagnated as farmers struggled with difficult soil and weather conditions.
stagnated as attacks by american indians impeded steady trade with europe.

The best and most correct answer among the choices provided by the question is the first choice "grew as they became centers of trade because of their location."
Quakers, Catholics, Jews, Lutherans and Presbyterians were among those religious groups that had significant numbers in the middle colonies. Economy – The Middle Colonies enjoyed a successful and diverse economy. Largely agricultural, farms in this region grew numerous kinds of crops, most notably grains and oats.

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