What were the three civilizations that began in mesopotamia

Mesopotamia (from the Greek, meaning 'between two rivers’) was an ancient region in the eastern Mediterranean bounded in the northeast by the Zagros Mountains and in the southeast by the Arabian Plateau, corresponding to today’s Iraq, mostly, but also parts of modern-day Iran, Syria and Turkey. The 'two rivers' of the name referred to the Tigris and the Euphrates rivers and the land was known as 'Al-Jazirah' (the island) by the Arabs referencing what Egyptologist J.H. Breasted would later call the Fertile Crescent, where Mesopotamiancivilization began.

Answer for apex - the reformation