Which trade routes were used for trade during the period of 500-1500

The english language is the primary language of europe

Can you show the answer choices?

True blindness may be caused by trauma to the eye, severe conjunctivitis due to  ibr (infectious bovine rhinoceros) or pink eye or other infections, leptospirosis, lead poisoning, selenium toxicity, fungal infections, vitamin a  deficiencies, rabies, vitamin b12 deficiency, neoplastic of the orbit or  conjunctiva, cataracts, congenital malformations, etc. 

Pacific