Which had the largest impact on the fall of Native American Empires, such as the Aztec and the Inca?

i believe its diseases

Explanation:

did you know that there where more people in the Americas than there where in Europe before the settlers came and gave them the diseases that wiped most of them out

john locke studied medicine and he laid a lot of groundwork for the enlightenment he also contibutied to the development of liberalism

if you could provide an excerpt for me to read i could