The significance of the Klondike region to the U. S. was the

The effects of the gold rush.

Explanation:

The influx of people to Dawson turned it into a legitimate city. It also led to a population boom in Yukon Territory, Alberta, British Columbia and Vancouver. The Klondike Gold Rush is credited for helping the United States out of a depression.

powers  are  denied  to the  national governmentin three distinct ways: some  powers, such as the  power  to levy duties on exports or prohibit the freedom of religion, speech, press, or assembly, are expressly  denied  to the  national government  in the  constitution.

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