What was the biggest effect of the European Exploration in the New World on the Native Americans?

What was the biggest effect of the European Exploration in the New World on the Native.

Explanation:trade routes to lucrative Asian markets and hoped to gain global recognition for their country.

trade routes to lucrative Asian markets and hoped to gain global recognition for their country.

Explanation:

in this way, as a created nation, france will probably use socio-economic reasons   at times do not take into account national economic, cultural, and social differences in protected industries. losing sovereignty, national independence.

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russia because it is the biggest state