The impetus for change that removed the isolation of europe in the middle ages was the blank

d. she conquered the black sea coast and parts of poland.

interdependence is when all participating groups and individuals depend on each other. if you depend on one anothers goods, you end up trading in order to get the items you're looking for. (for ex: if i have food and you have water, we trade in order to depend on each other to live)

d) all choices are correct