Which instrumentalist and vocalist from Seattle, Washington, was among the most original, inventive, and influential guitarist of the rock era as well as the most prominent African-American rock musician of the late 1960s?

Jimi Hendrix

Explanation:

James Marshall Hendrix or simply Jimi Hendrix is regarded the most influential guitarists. He is also the most celebrated musicians of the 20th century. He majorly played Rock, psychedelic rock, hard rock, blues and R&B.

Jimi was an instrumentalist and vocalist from Seattle, Washington, who ruled the 1960s and left a legacy after his tragic death. His music carried the essence of African-American rock.

The Rock and Roll Hall of Fame describes him as:

"the greatest instrumentalist in the history of rock music".

Explanation:

Jimi Hendrix was guitarist, singer and songwriter. His career lasted only for four years but still he is considered to be the most celebrated and influential musician in history of pop music.  

He taught himself to play the guitar, as he was left handed so he played the guitar upside down. He received seven music awards and was voted as the pop musician of the year. He was admitted  in the Rock and Roll Hall of Fame in 1992  and UK hall of fame in 2005.

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