What was the most significant motivation for prohibition?

The Anti-Saloon League, with strong support from Protestants and other Christian denominations, spearheaded the drive for nationwide prohibition. In fact, the Anti-Saloon League was the most powerful political pressure group in US history—no other organization had ever managed to alter the nation's Constitution.nation:

the  wilmot proviso  was designed to eliminate  slavery  within the  landacquired as a result of the mexican war (1846-48). fearing the addition of a pro-slave territory, pennsylvania congressman david  wilmot proposedhis amendment to the bill.

john locke is most associated with the idea of consent of the governed which is the idea that the government is only valid if it has the consent of the people who are being governed.

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