What factors affected the relationship between english colonist and american indians?

Some of the colonists were the "gentlemen" of English aristocracy who constituted a cancer from within. the Native Americans also had "bad eggs" also. unfortunate seasonal conditions may have brought out the worst of the worst in both

Do you have more info about it ? i doubt this is the answer because i don't have all the information but if trouble was brewing in a clinic maybe it was an argument as to which clinic was better or smth of that nature