A 36 year old woman on chronic cyclosporine treatment for bilateral lung transplantation visits the emergency department complaining of extreme headache, nausea and vomiting. Her exam is notable for BP 239/165, normal cardiac exam, bibasilar pulmonary rales, and 1+ lower extremity edema. EKG showed asymmetric inverted T-waves in I, aVL, and V4-6. In an effort to acutely control her blood pressure, which of the following is TRUE? Answers:
1.Esmolol works through both alpha-1 and selective beta-2 blockade

2.Hydralazine decreases myocardial oxygen demand by decreasing afterload and would not be useful in this setting

3.Nitroglycerin decreases BP by decreasing venous return and cardiac output

4.Nitroprusside would be contraindicated in this patient due to its relatively slow onset of action

5.Prolonged nitroprusside therapy may potentially cause methemoglobinemia