What are some of the challenges that could arise from setting up a file management system on a computer

Darren was recently ticketed for speeding over 110 mph on the freeway. when the police officer stopped darren and asked him why he was going so fast, he replied that he was "king of the world." the month before this, darren felt sad and listless and had trouble getting up the energy to go to school. he probably suffers from:

How does a bone marrow transplant treat sickle cell disease?

If a person has a bad pain in their back, specifically lower back a bit above the hip, what should they do besides going to the doctor? what remedies could they use?