Why are persons with down syndrome excluded from bone marrow transplant waiting lists?

Diseases may arise when proteins fail to fold correctly in their last stages of processing and/or are directed towards the lysosome rather than towards the cell membrane. cystic fibrosis is an example of this type of disease. in cystic fibrosis, a functional ion channel is sent to the lysosome for destruction rather than being sent to the plasma membrane. given this observation, the cellular component that is most likely the cause of the disease is the