It is the condition of the body to adapt to the effects of substances to the body thus requiring an even larger amount of the substance to experience the same physiological and mental effect.​

The statement refers to Drug tolerance.

Explanation:

Drug tolerance occurs when a person creates substance dependence, which consists in the fact that a psychoactive substance, administered to a person, must be progressively increased in its doses to achieve the same effects that previously occurred with the administration of lower doses, that is, it refers to the need to resort to increasing amounts of the substance to achieve the same desired effect.There is also evidence of Drug tolerance when with the same doses there is a notable decrease in the effects of the substance with its consumption continued. It occurs as a consequence of repeated consumption, which conditions that the intensity of the action of the substance is less and less.