As part of the innate defenses and specifically inflammation, fever - or abnormally high body temperature - is a systemic response to invading microorganisms. Leukocytes and macrophages that are exposed to foreign substances will secrete that will act on the body's "thermostat", which is located in .

ANSWER: PYROGENS; HYPOTHALAMUS

EXPLANATION: During invasion of foreign agents into the body system. The body acts in defense to the invading microbes, this response to foreign body causes inflammation, fever, or abnormal high blood temperature.

However, Leukocytes and macrophages that are present in the surrounding cell, that are exposed to the invading microorganism will secrete PYROGENS which will help to regulate the body's temperature, located in the HYPOTHALAMUS of the brain.

As part of the innate defenses and specifically inflammation, fever - or abnormally high body temperature - is a systemic response to invading microorganisms. Leukocytes and macrophages that are exposed to foreign substances will secrete pyrogenic cytokines  that will act on the body's "thermostat", which is located in hypothalamus.

Explanation:

These trigger the release by the blood leukocytes of a cascade of pyrogenic cytokines such as TNF-a, IL-1 and IL-6 (endogenous pyrogens), released mainly by macrophages and monocytes, as well as by Kupffer cells from the liver. .

These pyrogenic cytokines are responsible for triggering the hypothalamus to increase body temperature in order to denature the proteins of the infectious agent that invades the body, the failure of this innate defense mechanism is that it is not very selective, that is why it is so risky to have high fever, since not only the proteins of the virus, bacteria or other microorganisms are denatured, but also the proteins of the organism itself, triggering possible serious systematic failures.

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