The humoral immune response
a. involves mainly T cells and takes place in blood and lymph.
b. involves mainly B cells and takes place in blood and lymph.
c. involves mainly antibodies and takes place in blood and lymph.
d. involves mainly antigens and takes place in blood and lymph.

Involves mainly B cells and takes place in blood and lymph.

Explanation:

Humoral immune response: It is also known as antibody-mediated immunity and defined as the immune response which involves the transformation of B cells into plasma cells that help to obtain and secrete antibodies to a specific antigen.

The humoral immune system deals with antigens that come from pathogens that are freely circulating outside the infected cells. B cells are able to produce antibodies that will bind to the antigens and help them to neutralize, this process takes place in blood and lymph.

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