You are teaching a group of firefighters who are in class to become emergency medical responders. the topic is artificial ventilation with the bag-valve mask (bvm). which one of the following points related to using the bvm should you emphasize?
a. maintaining a good mask-to-face seal is difficult.
b. the bvm is useless unless it is hooked to supplemental oxygen.
c. it is better to ventilate too quickly as opposed to too slowly.
d. the bag must be fully squeezed in order to give a proper amount of volume with each breath.

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for