Chronic myelogenous leukemia (cml) is a type of cancer that is caused by a specific chromosomal alteration that leads to the inappropriate expression of a kinase called abl. kinases are enzymes that put phosphate groups onto macromolecules such as proteins. a drug used to treat cml, imatinib, binds to the active site of abl kinase. why does this drug work to treat this type of cancer?
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