Which issue is related to long-term cocaine use

Long-term cocaine use may result in stroke.

Explanation:

Cocaine is a stimulating drug that has an effect not only on the brain but also on vital body functions such as circulation and respiration. In the brain it acts at the core of pleasure. It will give the pleasant effect, of euphoria, of well being. In the heart it usually causes arrhythmia.

Cardiac arrhythmia increases the risk of coronary problems such as infarction and stroke. Cocaine generates a lot of adrenaline, generates increased pressure, increased heart rate and respiration, cardiac overload and thus has less blood reaching the heart and brain. For this reason, we can say that one of the long-term effects of using cocaine is stroke.

if you are asking how much they can go over the 1500 limit it would be safetly within the 2310 and 2600.mg

sure. but could you me with my question? ?