What is it when you can feel what feels like a little ball in your leg rolling around?

Spherocytosis is an inherited blood disease in which the erythrocytes (red blood cells) are spherical instead of biconcave. this condition is inherited in a dominant fashion, with sph- dominant to sph+. in people with spherocytosis, the spleen "reads" the spherical red blood cells as defective, and it removes them from the bloodstream, leading to anemia. the spleen in different people removes the spherical erythrocytes with different efficiencies. some people with spherical erythrocytes suffer severe anemia and some mild anemia, yet others have spleens that function so poorly there are no symptoms of anemia at all. when 2400 people with the genotype sph- sph+ were examined, it was found that 2250 had anemia of varying severity, but 150 had no symptoms. does this description of people with spherocytosis represent incomplete penetrance, variable expressivity, or both? explain your answer. (3 points)

What is the best thing for an applicat to do to prepare to write a cover letter

Josie decided to redecorate her son’s room. he is a toddler now and needs a bed instead of a crib. she packed up all of his infant toys and decided to donate them to his day care center. included in the box was a rattle that he had been quite attached to. he always pulled the small knob off the end of the rattle and josie would frequently reattach it. she thought that the knob was dangerous but nothing bad ever happened. some other kid might like to play with it now. 1. should josie have been concerned about the knob when her son first started removing it? why or why not? (2-3 sentences) 2. if she had reported the knob to the consumer product safety commission, what could the agency have done? (2-3 sentences) 3. if josie gives the box of toys to the day care center, what should the center director do? (2-3 sentences) 4. provide an appropriate substitute toy for her son at the age of infancy to replace the rattle. what does this toy promote for developmental wellbeing? you can include a picture or direct weblink to the toy, but do not forget your answer to the question regarding what does it promote for developmental wellbeing. (4-5 sentences) answer