The condition in which a drug user's body becomes so accustomed to a particular drug that it can only function normally if the drug is present is known as

The condition in which a person's body is so much used to a drug, that it works only in the presence of the drug, is known as dependence on the drug. This happens due to the addiction of the body towards the drug and the the drug is a part of many metabolic athways of the body. A basic level of drug is therefore required for normal functioning of the body. 

The investiture controversy began as a power struggle between pope gregory vii (1072–85) and henry iv, holy roman emperor (1056–1106).[2] a brief but significant struggle over investiture also occurred between henry i of england and pope paschal ii in the years 1103 to 1107, and the issue played a minor role in the struggles between church and state in france, as well.by undercutting the imperial power established by the salian emperors, the controversy led to nearly 50 years of civil war in germany, and the triumph of the great dukes and abbots. imperial power was finally re-established under the hohenstaufen dynasty. historian norman cantor: